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Online ISSN : 2349-8080 Issues : 12 per year Publisher : Excellent Publishers Email : editorinchiefijcrbp@gmail.com |
The global prevalence of Type 2 diabetes mellitus (T2DM) necessitates the exploration of safer, more effective therapies. This study investigates the antidiabetic potential of Momordica cymbalaria Hook. F. by leveraging green nanotechnology and an in vivo Drosophila melanogaster model. Calcium nanoparticles (CaNPs) were synthesized using methanolic extracts of M. cymbalaria fruit and root via an eco-friendly ionic precipitation method. EDAX analysis confirmed the elemental composition of Ca, O, and C, validating nanoparticle formation. Biochemical and behavioural assays were conducted on wild-type and vestigial mutant Drosophila strains subjected to a high-sucrose diet to induce diabetic phenotypes. Treated groups received either crude plant extracts or CaNP formulations. Results showed a significant improvement in locomotor performance, climbing assay, and marked restoration of antioxidant defenses, catalase activity. Diabetic flies exhibited elevated nitric oxide and glucose levels, which were significantly reduced upon treatment, particularly with seed crude extracts and CaNPs. Among treatments, seed-derived CaNPs demonstrated the most consistent efficacy across physical and biochemical parameters. The study highlights the therapeutic synergy between phytochemicals and nanotechnology. It also validates Drosophila as a robust model for screening traditional plant-based antidiabetic interventions. Findings support the integration of green-engineered plant nanoparticles in managing metabolic disorders and promote M. cymbalaria as a promising plant resource for future nanomedicine development.
