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Online ISSN : 2349-8080 Issues : 12 per year Publisher : Excellent Publishers Email : editorinchiefijcrbp@gmail.com |
Sargassum wightii (S. wightii) is a species of brown seaweed that is commonly found in the Indian Ocean and other tropical regions. Brown seaweed is rich in a range of bioactive compounds, including fucoidans, laminarin, alginates, and phlorotannins. After extraction, the crude extract is typically further purified using techniques such as Gas Chromatography Mass Spectrometry (GC-MS).The extracted secondary metabolites from S.wightii have a range of potential applications, including in the food, pharmaceutical, and cosmetic industries. Several methods have been employed for the extraction of secondary metabolites from S.wightii, including solvent extraction, microwave-assisted extraction, ultrasound-assisted extraction and supercritical fluid extraction. Solvent extraction is the most commonly used method, where solvents such as methanol, ethanol, acetone and chloroform are used to extract the metabolites. The present study aimed to investigate the phytochemical profile and anti-diabetic potential of S.wightii extracts. FT-IR spectroscopic analysis revealed the presence of bioactive compounds, including alkaloids, flavonoids, and phenolics. HPLC analysis identified methanolic extract.The anti-diabetic activity of the extracts was evaluated using alpha-amylase inhibition. The results demonstrated significant inhibition of alpha-amylase activity IC50 = 50.35 and enhancement of glucose uptake. These findings suggest that S.wightiiextracts possess potential anti-diabetic properties, warranting further investigation for the development of phyto-based treatments for diabetes management.
