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Online ISSN : 2349-8080 Issues : 12 per year Publisher : Excellent Publishers Email : editorinchiefijcrbp@gmail.com |
Cancer remains one of the most formidable health challenges, characterized by abnormal cell proliferation that invades and damages body tissues. Dodonaea viscosa, a plant with a rich history in traditional medicine, is known for its diverse medicinal properties. In this study, the leaves of D. viscosa were collected and subjected to extraction using methanol and chloroform. Phytochemical analysis revealed that the chloroform extract contained a higher concentration of bioactive compounds, including flavonoids, terpenoids, saponins, tannins, and phenols. Gas Chromatography-Mass Spectrometry (GC-MS) analysis further identified key bioactive metabolites such as Quinoline, 1,2-dihydro-2,2,3-trimethyl-, 1,1-Dodecanol, Dibutyl phthalate, Phthalic acid derivatives, and Oxirane octanoic acid methyl ester. Antibacterial assays demonstrated significant activity against E. coli and Staphylococcus aureus (MIC > 32 μg/mL). The antioxidant potential of the chloroform extract was confirmed by its radical scavenging activity, with the highest efficacy observed at a concentration of 100 µL. In anticancer studies, the extract exhibited potent activity against the MCF-7 breast cancer cell line, with an IC50 value of 8.571 μg/mL as determined by MTT assay. Trypan blue dye exclusion assay revealed 50% cell death, further confirming its cytotoxic potential. These findings highlight the therapeutic promise of Dodonaea viscosa leaf extracts, showcasing their antibacterial, antioxidant, and anticancer properties. This study supports the potential application of D. viscosa in developing treatments for various ailments, including cancer, and underscores the value of traditional medicinal plants in modern therapeutic research.
