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Abstract                 Volume:3  Issue-5  Year-2016          Original Research Articles

IJCRBP is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCRBP Articles.

Online ISSN : 2349-8080
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Identification of Pseudoknot in the Intergenic Region between VP30 and VP24 Gene of Ebola Virus and Designing Aptamer against the Pseudoknot
Damayanti Chakravarty1, Pankaj K. Singh2*, Sabdar Rahaman3 and Sayak Ganguli4
1Department of Food Science and Nutrition Management, J.D. Birla Institute, Kolkata-700 002, India
2 Bioinformatics Division, The Biome, Kolkata-700 064, India
3Department of Botany, Bangabasi Evening College, Kolkata-700 009, India 4Theoretical and Computational Biology Division, Amplicon Institute of Interdisciplinary Science and Technology,Palta-743 122, India
*Corresponding author
Abstract:

Ebola has been identified to be one of the most ominous pathogens capable of causing pandemic fatal disease in humans. Efforts are on to control the pathogen using various different therapeutic techniques and the vaccination effort is in its early second phase according to WHO sources. However, whether the candidate vaccine can confer “herd immunity” to a particular population remains a doubt. Thus alternative therapeutic approaches should be continuously explored, so as to combat the spread of the disease. In this work we attempt to identify one of the most predominant and essential RNA structural motifs - pseudoknot in the entire Ebola genome. The results indicate that a conserved pseudoknot motif is present in between the intergenic regions in between    VP 24 and VP 30.

Keywords: Antisense aptamer,Ebola virus,Pseudoknot
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How to cite this article:

Chakravarty, D., Singh, P. K., Rahaman, S., Ganguli, S., 2016. Identification of pseudoknot in the intergenic region between VP30 and VP24 gene of Ebola virus and designing aptamer against the pseudoknot.Int.J.Curr.Res.Biosci.Plantbiol. 3(5): 54-58. doi: http://dx.doi.org/10.20546/ijcrbp.2016.305.008
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.