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Abstract                 Volume:6  Issue-12  Year-2019          Original Research Articles

IJCRBP is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCRBP Articles.

Online ISSN : 2349-8080
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Statistical optimization of culture conditions for the production of bioactive compounds by Streptomyces spp. isolated from vermicasts
R. Balachandar1*, M. Prakash2 and N. Karmegam3
1Department of Biotechnology, Aarupadai Veedu Institute of Technology, Vinayaga Mission’s Research Foundation,Paiyanoor, Chennai – 603104, Tamil Nadu, India
2Department of Microbiology, Kanchi Shri Krishna College of Arts and Science, Kanchipuram-631551, Tamil Nadu, India
3Department of Botany, Government Arts College (Autonomous), Salem-636 007, Tamil Nadu, India
*Corresponding author
Abstract:

In the present work, the culture conditions appropriate for the maximum production of bioactive metabolites by Streptomyces spp. isolated from vermicasts were tested statistically. Two of the Steptomyces sp. isolated form vermicasts collected from Shervaroyan hills and Sirumalai hill ranges of southern Eastern Ghats were subjected to various environmental optimization conditions. These isolates were subjected to various physico-chemical parameters and the optimum conditions were identified for the maximum production of bioactive compounds with antimicrobial activity. AS1 showed a maximum biomass production in LB broth medium with a higher zone of inhibition against Bacillus circulans; whereas, AS3 showed a maximum biomass production and bioactive compound production in nutrient broth. Both isolates AS1 and AS3 showed maximum cell growth and zone of inhibition in the medium containing starch as a carbon source. For AS1, maximum growth and zone of inhibition was observed in the medium supplemented with casein as a nitrogen source.

Keywords:

Antimicrobial activity,Bioactive compounds,Media optimization,Streptomyces spp,Vermicasts

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How to cite this article:

Balachandar, R., Prakash, M., Karmegam, N., 2019. Statistical optimization of culture conditions for the production of bioactive compounds by Streptomyces spp. isolated from vermicasts.Int.J.Curr.Res.Biosci.Plantbiol. 6(12): 1-7. doi: https://doi.org/10.20546/ijcrbp.2019.612.001
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