Abstract                 Volume:6  Issue-1  Year-2019          Original Research Articles

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Antidiabetic effect of Afromomum meleguata ethanolic seed extract on streptozotocin induced diabetic Wistar rats
R .U. Ukpanukpong*1, D. O. Otu1, O. E. Olarinde2, R. O. Fafioye2, B. E. Ukwuondi1 and P. O. Igbineweka1
1Department of Biochemistry, University of Calabar, Calabar-Nigeria
2 Department of Chemical Sciences, Joseph Ayo Babalola University, Osun State -Nigeria
*Corresponding author
Abstract:

In the present investigation, attempt was made to evaluate the medicinal benefits of Afromomum meleguata in streptozotocin induced diabetic rats and validate its traditional claim. The extract treated groups were; 100mg/kg, 150mg/kg and 300mg/kg which showed significant decrease in blood glucose level compared to diabetic control group.  There was a significant increase in the body weight of extract treated rats when compared with the diabetic control group.  Therefore, the extracts at their administrative doses were safe. Significant increase was observed in PCV and Hb extract treated groups when compared with the control at P<0.05. The results for LDL of treated groups showed significant decrease (P<0.05) in the extract treated groups when compared with diabetic control group which may suggest that this plant may have some antilipidemic potentials. The levels of activities of serum transaminases enzymes; AST and ALT were decrease significantly in the extract treated groups compared with diabetic control group. The results depicts that Afromomum meleguata ethanolic seed extract possessed  a strong hypoglymic potency in streptozotocin induced diabetic rats, thus supporting its traditional use in diabetes mellitus control.

Keywords: Blood glucose level Body weight indices Haematological indices Lipid profile Phytochemical screening Serum enzyme activities
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How to cite this article:

Ukpanukpong, R. U., Otu, D. O., Olarinde, O. E., Fafioye, R. O., Ukwuondi, B. E., Igbineweka, P. O., 2019. Antidiabetic effect of Afromomum meleguata ethanolic seed extract on streptozotocin induced diabetic Wistar rats.Int.J.Curr.Res.Biosci.Plantbiol. 6(1): 19-28. doi: https://doi.org/10.20546/ijcrbp.2019.601.004