|Online ISSN : 2349-8080
Issues : 12 per year
Publisher : Excellent Publishers
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Ki-Zerbo, Burkina Faso 09 P.O Box 848 Ouagadougou 09
2National Center of Scientific and Technological Research, Institute of Environment and Agricultural Research, Burkina Faso, 01 P.O Box 476 Ouagadougou 01
Due to the various virulence factors produced and the growing resistance to antibiotics, Pseudomonas aeruginosa is the major cause of mortality in immunocompromised patients. Its pathogenicity regulated by the QS system lead to consider this mechanism of bacterial communication an opportunity for the control of infections caused by bacteria resistant to antibiotics. Thus, the ability of Acacia seyal bark extract to disrupt the cell-to-cell communication, to inhibit the production of virulence factors and biofilm formation was assessed in Pseudomonas aeruginosa PAO1. These investigations demonstrated that A. seyal bark extract inhibited significantly the production of QS-controlled virulence factors and biofilm formation without negatively affecting the growth of P. aeruginosa PAO1. These results suggest that A. seyal quenches the quorum sensing mechanism and could be a potent source for the research of new effective anti-QS drugs.