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Online ISSN : 2349-8080 Issues : 12 per year Publisher : Excellent Publishers Email : editorinchiefijcrbp@gmail.com |
Phospholipids are precursors of molecules with many distinct roles ranging from structural to signaling aspects of the cell. Phospholipids belong to Zwitterionic molecules. They ionize in both positive and negative mode. Alterations in particular lipid levels change cellular behavior. In humans, these changes may manifest as diseases such as the Alzheimer’s, atherosclerosis, diabetes, obesity, and even cancer formation. This has led to an enhanced interest in evaluating lipid changes both during normal cellular processes and in disease states. Along with the advent of rapid mass spectrometry, it has become possible to analyze many lipids within a single sample with unsurpassed sensitivity and detail. Coupling this with liquid chromatography potentially enables the complete profiling of all the phospholipids, both major and minor, from a single sample during a single analytical run.
