Abstract                 Volume:5  Issue-4  Year-2018          Original Research Articles

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The Antioxidant Properties of Momordica charantia Extract and its Protective Activities against In Vitro Mercury Intoxication
E. Orji*, A. E. Falodun and F. I. Jegede
Department of Science Technology and Glass and Ceramics Technology, Federal Polytechnic,Ado-Ekiti, Nigeria
*Corresponding author

Momordica charantia is a potent modulator of antioxidant and liver function indices. This research examines the antioxidant status of the extract and its protective effect on hepatic and renal system in vitro. The extract scavenges DPPH radicals in a concentration dependent manner and the reducing power of the extract increases with concentration. Thus, the homogenate were divided into five groups for the experiment. The group 1 is the control that has no intoxicant and extract. The group 2 contains homogenate and intoxicant while group 3 contains homogenate, intoxicant in dose dependent manner of 100ug/ml, 500ug/ml, and 1000ug/ml and likewise group 4, but no intoxicant. In group 5, the homogenate and intoxicant were treated with quercetin, a chelator used treatment of Hg poisoning.  According to result, the extract of Momordica charantia chelates iron in a concentration dependent manner, thus showing that the extract has iron chelating activity and acting as primary antioxidant. This study indicates that Hg administered group significantly reduced the concentration of kidney-sodium transport and decreased the activities of AST, ALT, GGT, leading to enzymes inactivation and degradation. Treatments with Momordica charantia extract help in bringing it back to near normal.

Keywords: Antioxidant,Homogenate,Intoxicant,Mercuric chloride,Momordica charantia
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How to cite this article:

Orji, E.E., Falodun, A.E., Jegede, F.I., 2018. The Antioxidant properties of Momordica charantia extract and its protective activities against in vitro mercury intoxication.Int.J.Curr.Res.Biosci.Plantbiol. 5(4): 30-35. doi: https://doi.org/10.20546/ijcrbp.2018.504.005