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2Department of Microbiology, Kanchi Shri Krishna College of Arts and Science, Kilambi, Kancheepuram-631 551, Tamil Nadu, India
The eathanolic leaf extracts of the medicinal plants, Euphorbia heterophylla and Tamilnadia uliginosa were tested for anti-inflammatory activity using carrageenan induced rat paw oedema. Wistar albino rats weighing about 180-200g were separated into 5 groups of 6 in each. The animals which served as positive control were given Diclofenac sodium (5mg/kg). The extract doses were administered orally one hour before commencing the experiments at a dose of 100, 200 and 400mg/kg body weight. The paw volume was measured at 0, 1, 3 and 5 hours after injection of carrageenan and percentage inhibition was calculated. The volume of paw oedema in carrageenan induced rats treated with ethanolic leaf extracts of Euphorbia heterophylla and Tamilnadia uliginosa was found to be concentration dependent. The ethanolic extract of Tamilnadia uliginosa leaf showed 0.906±0.036, 0.819±0.043 and 0.781 ±0.036 ml respectively in 100, 200 and 400 mg/kg treatment groups after 3rd hour of treatment. The maximum decrease of oedema volume (0.781 ±0.036 ml) was observed in 400 mg/kg treatment group after 3 hrs, next to diclofenac standard. Among the plant extracts tested, the leaf extract of Tamilnadia uliginosa showed highest percentage inhibition of 49.013 in 400 mg/kg treatment group 3 hrs after treatment. The study suggests that the ethanolic leaf extracts of Euphorbia heterophylla and Tamilnadia uliginosa are possessing anti-inflammatory activity.