Abstract                 Volume:5  Issue-3  Year-2018          Original Research Articles

IJCRBP is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCRBP Articles.

Online ISSN : 2349-8080
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The Effects of Aflatoxin B1 on Chromosome Aberrations and Sister Chromatid Exchanges in Human Lymphocytes
Awad A. Algarni*
Department of Biology, College of Science and Arts, Albaha University, Baljurashi, Saudi Arabia
*Corresponding author
Abstract:

Aflatoxin B1 (AFB1) is a ubiquitous mycotoxin produced by toxicogenic Aspergillus species. AFB1 has been reported to cause serious adverse health effects, such as cancers and abnormal development and reproduction, in animals and humans. The aim of this study was to investigate the ability of aflatoxin B1 (AFB1) to induce chromosome aberrations (CA) and sister chromatid exchanges (SCE) in human lymphocytes. AFB1 exposure significantly increased the number of CA and the frequency of SCE when compared with the control group. This significant increase in CAs as well as SCE may be attributed to the fact that AFB1 can induce genotoxicity through DNA damage. Thus, the present study indicates that AFB1 was genotoxic in human lymphocytes.

Keywords:

Aflatoxin B1,Chromosome aberrations Genotoxicity,Human lymphocytes

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How to cite this article:

Algarni, A. A., 2018. The effects of aflatoxin B1 on chromosome aberrations and sister chromatid exchanges in human lymphocytes.Int.J.Curr.Res.Biosci.Plantbiol. 5(3): 1-6. doi: https://doi.org/10.20546/ijcrbp.2018.503.001