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Abstract                 Volume:4  Issue-11  Year-2017          Original Research Articles

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Curative Effect of Ethanolic Extract of Medicinal Plants on Fluoride Induced Female Infertility Using Mice Model
Paramasivam Sivasakthi  and  Balamuthu Kadalmani*
Department of Animal Science, Bharathidasan University, Tiruchirappalli-620 024, Tamil Nadu, India
*Corresponding author

Female infertility, problems are increased gradually due to several reasons, especially environmental toxicity and water contaminations. Fluoride is the poisonous element, alters the hormonal regulation, folliculogenesis, ovulation and surface epithelial cell damage, finally, it creates infertility and risk of developing ovarian cancer. Sodium fluoride was administrated to female mice at 50, 100, 200ppm for 30d (days) through IP injection. After the fluoride treatment, three animals from each group were sacrificed and analyzed for biochemical parameters, hormone level and histopathological study. The remaining animals treated with ethanol extract of Tamarindus indica (T. indica) seed coat, Sida acuta root (S. acuta) and Tridax procumbens root (T. procumbens) at a daily dose of 100mg/kg bw for 15 days. The plant extracts treated animals were sacrificed to analyze the same process. In addition, histopathology of an ovarian surface are the irregular shape, follicle cell size and cells accumulations increased. Ethanolic extract of three medicinal plants reduced the fluoride toxicity S. acuta root extract was found to be more effective than other plant extracts.  The GC-MS report also had pharmacological properties that reduced the fluoride toxic. These plant extracts also revealed beneficial effect in the ovary, follicle cell count, hormone levels, and ovarian epithelial cell damage. The fluoride adverse effects on fertility are reversible when the extract treatment is observed in all three plants.

Keywords: Female mice, Fluoride, Infertility, Medicinal plant, Ovary
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How to cite this article:

Sivasakthi, P., Kadalmani, B., 2017. Curative effect of ethanolic extract of medicinal plants on fluoride induced female infertility using mice model.Int.J.Curr.Res.Biosci.Plantbiol. 4(11): 157-168. doi: https://doi.org/10.20546/ijcrbp.2017.411.014
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