Abstract                 Volume:4  Issue-11  Year-2017          Original Research Articles

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Chlorinated Plant Steroids and their Biological Activities
Valery M. Dembitsky1*, Tatyana A. Gloriozova2 and Vladimir V. Poroikov2
1 Biochemistry Laboratory, National Scientific Center of Marine Biology, 17 Palchevsky Str., Vladivostok, Russia 690041
2 Institute of Biomedical Chemistry, Moscow, Russia 119121                                                                                              
*Corresponding author
Abstract:

The present review describes the biological activities of natural plant chlorinated steroids. About forty biologically active chlorinated steroids have shown confirmed cytostatic, antineoplastic, anti-eczematic, antidiabetic, antibacterial, and other activities. The structures and reported and predicted activities of chlorinated steroids are available. With the computer programme PASS and based on structure–activity relationships (SAR), some additional activities are also predicted, which point towards new possible applications of these lipids. This review emphasizes the role of chlorinated steroids as an important source and potential leads for drug discovery and they are of great interest to chemists, physicians, biologists, pharmacologists and the pharmaceutical industry.

Keywords: Biological activities,Chlorinated steroids,Lipids,PASS,Structure–activity relationships
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How to cite this article:

Dembitsky, V. M., Gloriozova, T. A., Poroikov, V. V., 2017. Chlorinated plant steroids and their biological activities.Int.J.Curr.Res.Biosci.Plantbiol. 4(11): 70-85. doi: https://doi.org/10.20546/ijcrbp.2017.411.009