Abstract                 Volume:4  Issue-8  Year-2017          Original Research Articles

IJCRBP is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCRBP Articles.

Online ISSN : 2349-8080
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorinchiefijcrbp@gmail.com

Comparison between Populations of Black Pied and Holstein Cows and   Stud Bulls from Russia, Belarus and Kazakhstan by the Genetic Markers  for Resistance to Leukemia
Zalina Latypova1*, Sholpan Sarbakanova1, Saltanat Mamanova1, Akhmetzhan Sultanov1,Irina Nam2, Irina Smaznova3, Vladimir Zayakin3 and Alexandre Kozlov3
1Kazakh Scientific-Research Veterinary Institute, 050016, Republic of Kazakhstan, Almaty, Rayimbek Ave., 223
2Сenter for Innovation Transfer, Saint-Petersburg Academy of Veterinary Medicine, Russian Federation, Saint-Petersburg, Chernigov Str., 5
3Department of Chemistry, Bryansk State University named after Academician I.G. Petrovsky, Russian Federation, Bryansk, Bezhizk Str., 14                                                                         
*Corresponding author
Abstract:

Leukemia is one of the most common infectious diseases of cattle in Russia and Kazakhstan. The study is devoted to the analysis of genetic resistance to leukemia by PCR-RFLP in 716 cows (including 75 RID+ cows and 27 cows with hematological changes) and 81 Black Pied and Holstein stud bulls from the Bryansk and Leningrad regions (Russia), Kazakhstan and Belarus. To this end, we have examined the allele frequencies of BoLA-DRB3 gene related to the resistance (R) and susceptibility (S) to leukemia in various groups of animals. Cows from the breeding farms have 44.1-55.2% of S alleles, associated with susceptibility to leukemia, in the commercial farms they make up 20.1-29.4%. The total number of susceptibility S alleles in stud bulls ranges from 49.9% to 70.9%. In cows of all groups, the number of resistance alleles R to leukemia is far greater than in the bulls of all groups. It was shown that the number of S allele carriers is greater among RID+ cows. Analysis of 2 groups of sick cows has revealed that they include no animal units with RR genotype and only by 11-12% of cows with genotype R/S and R/N. The findings suggest the accumulation of S alleles to leukemia under holsteinization of the Black Pied breed, with increased risk of developing leukemia in animals.

Keywords:

Black pied cows,BoLA-DRB3 gene,Genetic resistance,Holstein cows,Leukemia,

Download this article as Download

How to cite this article:

Latypova, Z., Sarbakanova, S., Mamanova, S., Sultanov, A., Nam, I., Smaznova, I., Zayakin, V., Kozlov, A., 2017. Comparison between populations of Black Pied and Holstein cows and Stud bulls from Russia, Belarus and Kazakhstan by the genetic markers for resistance to leukemia.Int.J.Curr.Res.Biosci.Plantbiol. 4(8): 1-7. doi: https://doi.org/10.20546/ijcrbp.2017.408.001