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Online ISSN : 2349-8080 Issues : 12 per year Publisher : Excellent Publishers Email : editorinchiefijcrbp@gmail.com |
2PG Student and
3Professor and Head, Department of Pharmacology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
Coenzyme Q-10 which is lipid-soluble, vitamin-like substance and are present in most eukaryotic cells, primarily in the mitochondria is a component of the electron transport chain and participates in aerobic cellular respiration. The capacity of this molecule to exist in a completely oxidized form and a completely reduced form enables it to perform its functions in the electron transport chain and as an antioxidant respectively. Hyperglycemia in DM generates free radicals by mechanisms that are thought to involve metal catalyzed oxidation of glucose, oxidative degeneration and protein glycation. The presence of free radicals may account for diabetes and its complication. On this background the plan of this research work was made. Healthy male Wistar rats weighing between 150-250 grams were divided in four groups containing six animals in each group. Normal and diabetic animals were treated by placebo and coenzyme Q10 1.8mg/kg body weight respectively and investigated for fasting blood glucose levels. Blood glucose level in diabetic rats was significantly decreased in three weeks period. Therefore we can conclude that Coenzyme Q10 reduces the fasting blood sugar level in streptozotocin induced diabetic rats and it is of statistical significance in long term use (at 21 days and later).
