Abstract                 Volume:3  Issue-11  Year-2016          Original Research Articles

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Anti-diabetic Effects of Extract of Momordica charantia (Karela) Fruits and Camel Milk Compared to Dibenol on Induced Diabetic Rats
Kandil Abdel-Hai Ali Attia*$, Halima Yahya Sharahili, ShaimaAbd Al-ellah Al Harbi, Laila Mohammad Mutaen, Maraym Ali Somaly and Eman Abdu Qahar
Department of Medical Laboratory Technology, College of Applied Medical Sciences, Jazan University, Saudi Arabia
Current address: Department of Medical Laboratory Technology, College of Applied Medical Sciences, Jazan University, Saudi Arabia. Postal code: 82621/7431-P.O. Box: 2349
Permanent address: Evaluation of Natural Resources Department, Environmental Studies and Research Institute, University of El-Sadat City, El-Sadat City, Sixth Zone, Egypt
*Corresponding author

This study aimed to evaluate the anti-diabetic effects of aqueous extract of karela fruits and camel milk compared to dibenol on the streptozotocin (STZ) induced diabetic rats by assaying liver and kidney functions. Forty-two male albino rats were divided into 7 equal groups. Group I were given normal feed and water, groups II and III received orally (75 ml/rat/day) camel milk and extract of karela (800 mg/kg) respectively. Intraperitoneal injection of STZ (60 mg/kg) was used for inducing diabetes mellitus in groups IV, V, VI and VII. Groups V, VI and VII treated orally with dibenol (5mg/kg), camel milk and extract of karela respectively for 30 days. Blood glucose levels for each rat were determined before STZ dosing and after 3, 10, 30 days of administration. Blood samples were collected at the end of the experiment for estimation blood glucose concentration as well as kidney and liver functions parameters. The glucose level was decreased in rats treated with aqueous extract of karela or camel milk. Moreover, the ALT, AST, ALP enzymes, urea, creatinine and uric acid were decreased. It could be concluded that either karela or camel milk have anti-hyperglycemic effects and may be used to manage diabetes mellitus.

Keywords: Camel milk,Diabetes,Dibenol,Induced diabetic rats,Karela
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How to cite this article:

Attia, K. A. A., Yahya Sharahili, H., Abd Al-ellah Al Harbi, S., Mohammad Mutaen, L., Ali Somaly, M., Abdu Qahar, E., 2016. Anti-diabetic effects of extract of Momordica charantia (Karela) fruits and camel milk compared to dibenol on induced diabetic ratsInt.J.Curr.Res.Biosci.Plantbiol. 3(11): 1-8. doi: http://dx.doi.org/10.20546/ijcrbp.2016.311.001